diff --git a/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java b/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java
index 4b962d02ecb..daecc4f2090 100644
--- a/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java
+++ b/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java
@@ -94,7 +94,9 @@ public class SQLStateSQLExceptionTranslator extends AbstractFallbackSQLException
 			301,   // SAP HANA
 			1062,  // MySQL/MariaDB
 			2601,  // MS SQL Server
-			2627   // MS SQL Server
+			2627,  // MS SQL Server
+			-239,  // Informix
+			-268   // Informix
 		);
 
 
diff --git a/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java b/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java
index 94abeccca32..263eb8f829d 100644
--- a/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java
+++ b/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java
@@ -90,6 +90,16 @@ class SQLStateSQLExceptionTranslatorTests {
 		assertTranslation("23000", 301, DuplicateKeyException.class);
 	}
 
+	@Test
+	void translateDuplicateKeyInformix1() {
+		assertTranslation("23000", -239, DuplicateKeyException.class);
+	}
+
+	@Test
+	void translateDuplicateKeyInformix2() {
+		assertTranslation("23000", -268, DuplicateKeyException.class);
+	}
+
 	@Test
 	void translateDataAccessResourceFailure() {
 		assertTranslation("53", DataAccessResourceFailureException.class);
diff --git a/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java b/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java
index 8741f89067f..33d8a7619b8 100644
--- a/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java
+++ b/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java
@@ -76,7 +76,9 @@ public abstract class ConnectionFactoryUtils {
 			301,   // SAP HANA
 			1062,  // MySQL/MariaDB
 			2601,  // MS SQL Server
-			2627   // MS SQL Server
+			2627,  // MS SQL Server
+			-239,  // Informix
+			-268   // Informix
 		);
 
 
diff --git a/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java b/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java
index 49861f0a4e8..902d4ce8514 100644
--- a/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java
+++ b/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java
@@ -25,7 +25,9 @@ import io.r2dbc.spi.R2dbcRollbackException;
 import io.r2dbc.spi.R2dbcTimeoutException;
 import io.r2dbc.spi.R2dbcTransientResourceException;
 import org.junit.jupiter.api.Test;
-
+import org.junit.jupiter.params.ParameterizedTest;
+import org.junit.jupiter.params.provider.Arguments;
+import org.junit.jupiter.params.provider.MethodSource;
 import org.springframework.dao.CannotAcquireLockException;
 import org.springframework.dao.DataAccessResourceFailureException;
 import org.springframework.dao.DataIntegrityViolationException;
@@ -37,8 +39,12 @@ import org.springframework.dao.TransientDataAccessResourceException;
 import org.springframework.r2dbc.BadSqlGrammarException;
 import org.springframework.r2dbc.UncategorizedR2dbcException;
 
+import java.util.stream.Stream;
+
 import static org.assertj.core.api.Assertions.assertThat;
 
+
+
 /**
  * Tests for {@link ConnectionFactoryUtils}.
  *
@@ -86,35 +92,32 @@ class ConnectionFactoryUtilsTests {
 		assertThat(exception).isExactlyInstanceOf(DataAccessResourceFailureException.class);
 	}
 
+	private static Stream<Arguments> duplicateKeyErrorCodes() {
+		return Stream.of(
+				Arguments.of("Oracle", "23505", 0),
+				Arguments.of("Oracle", "23000", 1),
+				Arguments.of("SAP HANA", "23000", 301),
+				Arguments.of("MySQL/MariaDB", "23000", 1062),
+				Arguments.of("MS SQL Server", "23000", 2601),
+				Arguments.of("MS SQL Server", "23000", 2627),
+				Arguments.of("Informix", "23000", -239),
+				Arguments.of("Informix", "23000", -268)
+		);
+	}
+
+	@ParameterizedTest
+	@MethodSource("duplicateKeyErrorCodes")
+	void shouldTranslateIntegrityViolationException(final String db, String sqlState, final int errorCode) {
+		Exception exception = ConnectionFactoryUtils.convertR2dbcException("", "",
+				new R2dbcDataIntegrityViolationException("reason", sqlState, errorCode));
+		assertThat(exception).as(db).isExactlyInstanceOf(DuplicateKeyException.class);
+	}
+
 	@Test
-	void shouldTranslateIntegrityViolationException() {
+	void shouldTranslateGenericIntegrityViolationException() {
 		Exception exception = ConnectionFactoryUtils.convertR2dbcException("", "",
 				new R2dbcDataIntegrityViolationException());
 		assertThat(exception).isExactlyInstanceOf(DataIntegrityViolationException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23505"));
-		assertThat(exception).isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 1));
-		assertThat(exception).as("Oracle").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 301));
-		assertThat(exception).as("SAP HANA").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 1062));
-		assertThat(exception).as("MySQL/MariaDB").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 2601));
-		assertThat(exception).as("MS SQL Server").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 2627));
-		assertThat(exception).as("MS SQL Server").isExactlyInstanceOf(DuplicateKeyException.class);
 	}
 
 	@Test