diff --git a/spring-core/spring-core.gradle b/spring-core/spring-core.gradle
index d9ce7201e8d..c80a60849fa 100644
--- a/spring-core/spring-core.gradle
+++ b/spring-core/spring-core.gradle
@@ -60,6 +60,7 @@ dependencies {
 	optional("io.smallrye.reactive:mutiny")
 	optional("io.netty:netty-buffer")
 	testImplementation("jakarta.annotation:jakarta.annotation-api")
+	testImplementation("jakarta.inject:jakarta.inject-api")
 	testImplementation("jakarta.xml.bind:jakarta.xml.bind-api")
 	testImplementation("com.google.code.findbugs:jsr305")
 	testImplementation("com.fasterxml.woodstox:woodstox-core")
diff --git a/spring-core/src/main/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrar.java b/spring-core/src/main/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrar.java
index a8ad865e823..30480b3c5ec 100644
--- a/spring-core/src/main/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrar.java
+++ b/spring-core/src/main/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrar.java
@@ -23,6 +23,7 @@ import org.springframework.aot.hint.RuntimeHintsRegistrar;
 import org.springframework.core.annotation.AliasFor;
 import org.springframework.core.annotation.Order;
 import org.springframework.lang.Nullable;
+import org.springframework.util.ClassUtils;
 
 /**
  * {@link RuntimeHintsRegistrar} for core annotations.
@@ -36,6 +37,10 @@ class CoreAnnotationsRuntimeHintsRegistrar implements RuntimeHintsRegistrar {
 	public void registerHints(RuntimeHints hints, @Nullable ClassLoader classLoader) {
 		Stream.of(AliasFor.class, Order.class).forEach(annotationType ->
 				RuntimeHintsUtils.registerAnnotation(hints, annotationType));
+		if (ClassUtils.isPresent("jakarta.inject.Inject", classLoader)) {
+			Stream.of("jakarta.inject.Inject", "jakarta.inject.Qualifier").forEach(annotationType ->
+					RuntimeHintsUtils.registerAnnotation(hints, ClassUtils.resolveClassName(annotationType, classLoader)));
+		}
 	}
 
 }
diff --git a/spring-core/src/test/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrarTests.java b/spring-core/src/test/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrarTests.java
index d21f25fe8c2..94d63183381 100644
--- a/spring-core/src/test/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrarTests.java
+++ b/spring-core/src/test/java/org/springframework/aot/hint/support/CoreAnnotationsRuntimeHintsRegistrarTests.java
@@ -16,6 +16,8 @@
 
 package org.springframework.aot.hint.support;
 
+import jakarta.inject.Inject;
+import jakarta.inject.Qualifier;
 import org.junit.jupiter.api.BeforeEach;
 import org.junit.jupiter.api.Test;
 
@@ -59,4 +61,16 @@ class CoreAnnotationsRuntimeHintsRegistrarTests {
 				.withMemberCategory(MemberCategory.INVOKE_DECLARED_METHODS)).accepts(this.hints);
 	}
 
+	@Test
+	void jakartaInjectAnnotationHasHints() {
+		assertThat(RuntimeHintsPredicates.reflection().onType(Inject.class)
+				.withMemberCategory(MemberCategory.INVOKE_DECLARED_METHODS)).accepts(this.hints);
+	}
+
+	@Test
+	void jakartaQualifierAnnotationHasHints() {
+		assertThat(RuntimeHintsPredicates.reflection().onType(Qualifier.class)
+				.withMemberCategory(MemberCategory.INVOKE_DECLARED_METHODS)).accepts(this.hints);
+	}
+
 }